CARBACYCLIN Property

Melting point:

65-67℃

Boiling point:

514.8±50.0 °C(Predicted)

Density 

1.177±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

Soluble at 20mg/ml in ethanol.

pka

4.77±0.10(Predicted)

form 

Solid

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

22-36

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

CARBACYCLIN Chemical Properties,Usage,Production

Uses

Carbacyclin acts as a converter of human white to bright adipocytes. Also used in the treatment of high-risk acute lymphoblastic leukemia potentiating the activity of anti-cancer therapeutics.

Uses

Carbacyclin is a stable analog of PGI2. When infused in rabbits or dogs, it inhibits ex vivo platelet aggregation, but the effect persists only 10 minutes after termination of the infusion. Carbacyclin is a stable analog of PGI2. Carbacyclin inhibits platelet aggregation with 10% of the molar potency exhibited by PGI2. The ED50 of Carbacyclin for the in vitro inhibition of ADP-induced platelet aggregation in human PRP is 47 nM. It was also shown to effect terminal differentiation of preadipose into adipose cells and enhance the expression of angiotensinogen and adipose fatty acid binding protein with an EC50 of about 0.5 μM.

Definition

ChEBI: Carbaprostacyclin is a prostanoid.